- cycloergostanol is a complex steroid derivative belonging to the class of phytosterols or ergostane-type steroids, often found in fungi, lichens, and some medicinal plants. structurally related to ergosterol, cycloergostanol compounds have been studied for their potential anticancer, antimicrobial, and anti-inflammatory activities. they feature a cyclopropane ring and multiple methyl substitutions in their sterol backbone.
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chemical properties
- molecular weight: varies depending on side chains; typical derivatives ~470–490 g/mol
- structure: tetracyclic sterol nucleus with cyclopropyl or methylated side groups
- melting point: estimated range 160–190°C
- solubility: lipid-soluble; insoluble in water
- chemical formula: C₃₀H₅₀O (for common cycloergostanol acetate derivatives)
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usefulness in medicine
- cycloergostanol derivatives exhibit potential anticancer effects by inducing apoptosis and inhibiting cell proliferation in tumor cells.
- they show anti-inflammatory activity, particularly by downregulating pro-inflammatory cytokines.
- some compounds have demonstrated neuroprotective potential in preclinical studies.
- used as lead structures for drug discovery in steroid-based pharmacology.
- their bioactivity depends on structural variations like acetate esters or oxidation states.
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