beta-sitosterol

• beta-sitosterol is a naturally occurring phytosterol found in many plants, including nuts, seeds, fruits, and vegetables. it has a chemical structure similar to cholesterol and is known for its ability to reduce cholesterol absorption in the human gut. beta-sitosterol is used for supporting cardiovascular health, managing symptoms of benign prostatic hyperplasia (bph), and enhancing immune function.

  • chemical properties

    • molecular weight: 414.7 g/mol
    • structure: steroid nucleus with a side chain; structurally similar to cholesterol
    • melting point: ~137–139°C
    • solubility: insoluble in water; soluble in ethanol, chloroform, and oils
    • chemical formula: C₂₉H₅₀O

  • usefulness in medicine

    • beta-sitosterol helps lower ldl cholesterol levels by competing with dietary cholesterol for absorption.
    • it is used in the treatment of bph to improve urinary symptoms in men.
    • it has anti-inflammatory effects that may benefit people with arthritis and autoimmune conditions.
    • beta-sitosterol is also investigated for potential anticancer effects, particularly in prostate and breast cancer models.
    • it may support immune balance and oxidative stress reduction.

  • antibacterial and antimicrobial activity

    • beta-sitosterol exhibits moderate antimicrobial effects against certain bacteria and fungi.
    • it can disrupt microbial cell membranes and reduce inflammation caused by infection.
    • often works synergistically with other plant compounds in extracts.
    • research highlights:
      • bacteria:
        • escherichia coli research link
        • salmonella typhi research link
      • fungi:
        • candida albicans research link

• research links

  • beta-sitosterol and cholesterol
  • beta-sitosterol and bph
  • beta-sitosterol antimicrobial activity